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The vision of the ACT project is to create a CTSA federated network to increase accrual to clinical trials.


The fundamental purpose of the ACT project is to improve patient care and enable clinical trials and translational research.

Welcome to the ACT Network

The ACT Network is a nationwide network of sites that share EHR data to to significantly increase participant accrual to the nation’s highest priority clinical trials. It is funded by NCATS’ Clinical and Translational Science Awards (CTSA) program that supports efforts to solve system-wide translational research problems to improve the success of U.S. clinical trials.

“We are approaching the challenge of identifying and enrolling patients by linking EHRs to identify potential participants who meet study criteria,” said Steven E. Reis, M.D., a professor and associate vice chancellor for clinical research at the University of Pittsburgh, and director of the University of Pittsburgh Clinical & Translational Science Institute. He added that the ACT team created standard categories and terminology for demographic and clinical visit data as well as for medications and laboratory results. “Recruiting participants into clinical trials is a critical success factor in our ability to bring more treatments to more patients more quickly,” said Petra Kaufmann, M.D., M.Sc., NCATS Division of Clinical Innovation director. “The CTSA ACT investigators are tackling this challenge using innovative tools not only to find out where potential participants are, but they also are beginning to look at better ways to then connect participants with research opportunities.”